Post by the Scribe on Mar 28, 2022 2:16:34 GMT
Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria
sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2672.2012.05253.x#:~:text=The%20bactericidal%20activity%20of%20silver%20nanoparticles%20against%20the,aureus%20%28MRSA%29%20and%20vancomycin-%20resistant%20Staphylococcus%20aureus%20%28VRSA%29
M.K. Rai,S.D. Deshmukh,A.P. Ingle,A.K. Gade
Conclusions
Continuous increase in resistance to drug/antibiotics in human pathogens leads to the re-emergence of MDR pathogens and parasites. Infections caused by such pathogens require a multiple treatment, containing broad-spectrum antibiotics. In fact, these treatments are less effective, more toxic and also expensive. Nanotechnology provides a good platform to overcome the problem of resistance, with the help of the silver nanoparticles. Since the ancient time, antimicrobial efficacy of silver was reported in Ayurveda and homoeopathy. The bactericidal potential can be increased by manipulating the size at nanolevel, leading to increased surface-area-to-volume ratio and also by changing the chemical and physical properties. Silver nanoparticles of size 10–100 nm have strong bactericidal potential against both Gram-positive and Gram-negative bacteria. Therefore, silver nanoparticles having bactericidal potential would be used as powerful weapons against the MDR bacteria such as Ps. aeruginosa, ampicillin-resistant E. coli, erythromycin-resistant Strep. pyogenes, MRSA and VRSA.