Post by the Scribe on Jun 16, 2023 0:41:14 GMT
Mega-Dose Thiamine: Benefits Beyond Addressing Deficiency
EONutrition
287,255 views Dec 28, 2020
In this video, I will explain the rationale behind high-dose thiamine therapy as a tool for bypassing metabolic blocks caused by factors unrelated to nutritional deficiency, and examine how this can be a useful therapy for chronic health conditions characterized by mitochondrial dysfunction.
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I have come to the conclusion that one does not need to be deficient (in the nutritional sense) to benefit from this type of therapy, because high-dose thiamine is not simply working by correcting nutritional deficiency.
Rather, thiamine is functioning as a metabolic stimulant to restore oxidative energy metabolism in cells that has been inhibited by factors unrelated to nutritional status.
Overwhelming toxicity and chronic oxidative stress have the capacity to inactivate thiamine-dependent enzymes involved in the generation of cellular energy, producing biochemical changes which are similar to clinical thiamine deficiency. This could basically be referred to as “functional” thiamine deficiency.
In a functional deficiency dietary thiamine intake is somewhat irrelevant, because the concentrations obtained via the diet are simply not sufficient to overcome enzymatic inactivation.
Instead, extremely high concentrations of thiamine are often necessary to overcome the “metabolic block” and restore the deranged metabolism back to normal. Dr Derrick Lonsdale has discussed this concept on many occasions and laid out the theory in his various writings.
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